How It Works
An overview of how the Migraine Detective Method is applied in practice.
The Process
Simple structure. No mystery.
A clear, repeatable way to investigate migraine - without guesswork.
This is not a one-time fix. It's an investigative loop that gets clearer with each pass.
~1-2 weeks
Gather Your Clues™
Start with a short quiz to map your migraine history, then build your case file - prior tests, imaging, symptom timing, patterns, and past treatments.
Take the Quiz →Goal: A longitudinal view where meaningful signals emerge that are invisible in isolation.
Case review session
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Upload your results, journals, and history. Our migraine-specific AI - trained to reason across symptoms, timing, and physiology - finds patterns and generates your personalized Hypothesis Map.
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Output: A short list of testable hypotheses (not guesses).
3-6 months (iterative)
Test Your Hypotheses™
Test one hypothesis at a time. This may involve targeted testing, controlled changes, or timing- and dose-based experiments.
Goal: Learn what actually moves the needle - without stacking changes or muddying signals.
Ongoing
Iterate & Refine
Results become new clues. Each response - improvement, no change, or worsening - feeds back into the case file. Then we refine the hypothesis, peel back the next layer, and test again with more precision.
Goal: This loop continues until patterns are no longer ambiguous and decisions become obvious.
This is not a straight line. It's a loop.
Gather → Detect → Test → Learn → Repeat
Each cycle reduces uncertainty. Each iteration sharpens the signal.
Nothing is wasted - even "failed" tests add clarity.
What this replaces
Random supplements, stacking changes, chasing labs, and restarting from scratch.
What this creates
A clear investigative path that compounds over time.
What an Investigation Looks Like
Sample Report of Findings (Illustrative Example)
This example shows how the Migraine Detective Method is applied in practice. It is shared for educational purposes only and does not represent medical advice, diagnosis, or treatment.
Step 1: Gather Your Clues™
Case Context
10+ years of migraines with extensive prior testing, treatments, and lifestyle changes.
Data Collected
Multi-year blood work, MRI/MRA imaging, medication and supplement history, symptom timing, diet, hydration, sleep, and hormonal context.
Key Insight
The goal was not more data, but reviewing existing data together and over time.
Step 2: Migraine Detective™
Fluid & Vascular Pattern
A persistently altered BUN-to-creatinine ratio appeared across multiple years. While initially dismissed as situational (e.g., dehydration), its consistency over time suggested a recurring signal rather than a one-time issue.
Histamine-Related Pattern
A histamine-related pattern was considered despite the absence of classic allergy symptoms, informed by dietary exposure and genetic context. Follow-up 24-hour urine histamine testing, requested through a licensed clinician, returned values ~30% above the laboratory reference range.
Hormonal Modulation
Symptom timing shifted with hormonal phases and changes such as HRT, suggesting hormones acted as modulators rather than a single cause.
Drainage & Sleep Factors
Review of prior imaging showed MRI and MRA results reported as within normal limits, but no MRV had been performed. Additional imaging filled this gap and revealed venous flow irregularities associated with positional and morning symptoms.
Step 3: Test Your Hypotheses™
A. Hypotheses Explored
- •Histamine-related pathway
- •Fluid & vascular regulation
- •Drainage & sleep-related factors
- •Hormonal modulation across cycle phases
B. Data Used to Evaluate Each Hypothesis (with a clinician)
- •24-hour urine histamine testing
- •Renin and aldosterone levels
- •MRV (magnetic resonance venography)
- •Estradiol levels measured in follicular and luteal phases
C. Guiding Principle
Hypotheses were explored one at a time. Each result informed the next decision, and all changes were treated as temporary experiments, not permanent solutions.
Outcome
What Changed
Migraines became interpretable rather than random. Patterns replaced guesswork, and testing became intentional.
Why This Matters
When there is no single definitive test, progress comes from structured investigation and learning from each experiment.
This example is illustrative and educational. Individual experiences vary, and all medical decisions are made with a licensed clinician.
Understand how prior labs, imaging, and symptom history are analyzed together.
See How Testing Is Used →